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TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells.
Yu DC, Chen XY, Zhou HY, Yu DQ, Yu XL, Hu YC, Zhang RH, Zhang XB, Zhang K, Lin MQ, Gao XD, Guo TW. Yu DC, et al. Mol Biol Rep. 2022 Apr;49(4):3055-3064. doi: 10.1007/s11033-022-07133-6. Epub 2022 Jan 15. Mol Biol Rep. 2022. PMID: 35032258
This study investigated early diagnosis and treatment objectives using bioinformatics strategies and performed experimental verification. METHODS AND RESULTS: The top 10 OS hub genes-CCNA2, CCNB1, AURKA, TRIP13, RFC4, DLGAP5, NDC80, CDC20, CDK1, and KIF20A-were scre …
This study investigated early diagnosis and treatment objectives using bioinformatics strategies and performed experimental verificat …
An interaction network driven approach for identifying biomarkers for progressing cervical intraepithelial neoplasia.
Suman S, Mishra A. Suman S, et al. Sci Rep. 2018 Aug 27;8(1):12927. doi: 10.1038/s41598-018-31187-x. Sci Rep. 2018. PMID: 30150654 Free PMC article.
Two significant modules and 10 hubs of the common gene interaction network, with 125 nodes and 201 edges were found. DEGs namely NDC80, ZWINT, CDC7, MCM4, MCM2 and MCM6 were found to be common in both the significant modules as well as the hubs. ...Capitalizing upon and ta …
Two significant modules and 10 hubs of the common gene interaction network, with 125 nodes and 201 edges were found. DEGs namely NDC80 …
Spindle pole body component 25 regulates stemness of prostate cancer cells.
Cui F, Tang H, Tan J, Hu J. Cui F, et al. Aging (Albany NY). 2018 Nov 8;10(11):3273-3282. doi: 10.18632/aging.101631. Aging (Albany NY). 2018. PMID: 30408771 Free PMC article.
Spindle pole body component 25 (SPC25) is a component of NDC80 complex that controls spindle assembly checkpoint in the microtubule-binding domain of kinetochores. ...
Spindle pole body component 25 (SPC25) is a component of NDC80 complex that controls spindle assembly checkpoint in the microtubule-b …
Effects of targeting highly expressed in cancer protein 1 (Hec1) inhibitor INH 1 in breast cancer cell lines In Vitro.
Topçul M, Çetin İ. Topçul M, et al. Cell Mol Biol (Noisy-le-grand). 2023 Dec 20;69(14):109-113. doi: 10.14715/cmb/2023.69.14.17. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 38279468
According to the findings of the current study, INH1 altered cell proliferation by lowering cell viability, CI, MI values, and BrdU proliferation while raising AI values in both cell lines. Between the experimental and control groups, there were noticeable changes (p<0. …
According to the findings of the current study, INH1 altered cell proliferation by lowering cell viability, CI, MI values, and BrdU prolifer …
Screening of hub genes and evaluation of the growth regulatory role of CD44 in metastatic prostate cancer.
Lin J, Chen Z, Li Z, Nong D, Li X, Huang G, Hao N, Liang J, Li W. Lin J, et al. Oncol Rep. 2021 Sep;46(3):196. doi: 10.3892/or.2021.8147. Epub 2021 Jul 23. Oncol Rep. 2021. PMID: 34296309 Free PMC article.
The results of the protein-protein interaction network revealed that the hub genes in mPCa were separately PTEN, Rac GTPase-activating protein 1, protein regulator of cytokinesis 1, PDZ binding kinase, centromere-associated protein E, NUF2 component of NDC80 kinetochore co …
The results of the protein-protein interaction network revealed that the hub genes in mPCa were separately PTEN, Rac GTPase-activating prote …
Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy.
Chuang SH, Lee YE, Huang LYL, Chen CK, Lai CL, Lin YH, Yang JY, Yang SC, Chang LH, Chen CH, Liu CW, Lin HS, Lee YR, Huang KP, Fu KC, Jen HM, Lai JY, Jian PS, Wang YC, Hsueh WY, Tsai PY, Hong WH, Chang CC, Wu DZ, Wu J, Chen MH, Yu KM, Chern CY, Chang JM, Lau JYN, Huang JJ. Chuang SH, et al. Eur J Med Chem. 2020 Apr 1;191:112118. doi: 10.1016/j.ejmech.2020.112118. Epub 2020 Feb 7. Eur J Med Chem. 2020. PMID: 32113126
Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.
Park I, Lee HO, Choi E, Lee YK, Kwon MS, Min J, Park PG, Lee S, Kong YY, Gong G, Lee H. Park I, et al. J Cell Biol. 2013 Jul 22;202(2):295-309. doi: 10.1083/jcb.201210099. J Cell Biol. 2013. PMID: 23878276 Free PMC article.
The association of acetylation-deficient BubR1 with PP2A-B56alpha phosphatase was reduced, and the phosphorylated Ndc80 at the KT was elevated in K243R/+ MEFs. In relation, there was a marked increase of micronuclei and p53 mutation was frequently detected in primary tumor …
The association of acetylation-deficient BubR1 with PP2A-B56alpha phosphatase was reduced, and the phosphorylated Ndc80 at the KT was …